proin vs incurin

Took her to the vet and we are switch to Incurin as of yesterday. 59, 673-679. Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. A long-term evaluation of cases treated by the author indicates that a cure-rate of approximately 50% can be expected with most of the remaining bitches improved. The vet will determine the dogs usual dose. Cancel or update at anytime. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. You cannot paste images directly. Maybe you could try it. In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. We now have a prescription for DES. Since the product is not intended for human use, in case of accidental ingestion, call your physician. Incurin for Dogs. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. Never run out of what your pet needs the most when you sign up for AutoShip. Flea Pills for Dogs: The Ultimate Guide Every Pet Owner Must Read, Cephalexin For Dogs: Recommended Dosage, Side Effects, and More, Enalapril for Dogs: Side Effects, Dosage, and More, Colloidal Silver For Dogs: A Natural Antibiotic for Sick Dogs. Use of decongestants during pregnancy and the risk of birth defects. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression.4 In the authors experience, therapy with estrogen-based products, such as estriol (Incurin; Merck Animal Health, merck-animal-health-usa.com), is preferable for patients with known behavioral concerns. Were sorry, but our website doesnt work properly without JavaScript enabled. Looks like it was approved in March 2000. It is not labeled for use in dogs weighing less than 10 pounds.10 Owing to a lack of safety and efficacy studies, using Proin ER tablets and Proin chewable tablets interchangeably is not recommended, nor is the use of Proin in pregnant or lactating animals.10. JAVMA. 1979;49:4665. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. 93% of dogs treated with Incurin were improved or continent by 6 weeks, 51% of dogs were titrated down to doses less than 2 mg daily; of these, 99% were improved or continent by 6 weeks. 15. Journal of Small Animal Practice 42, 481-486. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. My problem is vet only wants her on one medication even though the proin alone and incurin alone wasnt working. & Barr, F.J. (1998) Ultrasonographic assessment of bladder neck mobility in continent bitches and bitches with urinary incontinence attributable to urethral sphincter mechanism incompetence. Kari and the pups.Run free sweet Hana 9/21/08-9/12/10. awesome - thanks for the info. prnpharmacal.com/products/urinary-health/proin-er. That is encouraging. Dr. Snell received her DVM from Texas A&M University and has completed a rotating internship at Louisiana State University. I asked if peeing hurts her (medically) and he said no, just her pride. Well tolerated in a long-term field study (42-month) involving 324 client-owned ovariohysterectomized female dogs. After the initial load we only had to give her one pill a week, which is hardly anything. 1984;20(4B):10051013.1. 15. Can I Give My Dog Aspirin? Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Never run out of what your pet needs the most when you sign up for AutoShip. A similar variation in response is also seen with the use of alpha-adrenergic drugs Oestrogens sensitise the urethral smooth muscle to alpha-adrenergic stimulation and so a combination of oestrogen and alpha-adrenergic therapy may be useful and reduce the dose of each individual drug, lessening the chances of side effects. The most common side effects Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Madison, NJ: Intervet Inc.; 2011. Association of sympathomimetic drugs with malformations. October 2020. Flexible The greater experiences of medical urologists treating incontinent women suggests that colposuspension provides firmer anchorage of the lower urogenital tract than urethropexy and avoids urethral trauma. 18. 17. Accessed October 2020. 5. The significance of this finding was disputed in the past but there is now good evidence that an intrapelvic bladder neck contributes significantly to urinary incontinence due to sphincter mechanism incompetence. Dogs should not receive more than 2 mg of Incurin per day (2 tablets). is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. That will teach you to keep your mouth shut." Note: Any trademarks are the property of their respective companies. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. Took her in for a lot of tests and the vet came back with older fixed female dogs have this problem some times and prescribed her proin. Dr. Byron is a clinical professor in the department of veterinary clinical sciences at the Ohio State University (OSU) College of Veterinary Medicine. I guess I meant when . with Rainey, she started urinating (and defecating) whenever we'd leave -- even if it was just for 40 minutes. 1988;32(2):273-280. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. Yeah i think it does hurt their pride a bit - Seal always seemed embarrassed when her UI first occurred. 16. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. (1990) Long-term evaluation of colposuspension in the treatment of urinary incontinence due to incompetence of the urethral sphincter mechanism in the bitch. My cat is currently throwing up white foam and hiding all My dog hasn't eaten in over 10 days. It can present as a congenital or acquired condition. Seems to do well for those I know that take it. Also, do you know why it may be safer than DES? Clark JH, Hardin JW, McCormack SA. We never reprimanded her for it of course, since she couldn't help it, but she would often try to lick the spot on her bed to cover up the evidence. Aust Vet J. Georgie is otherwise a healthy, active girl with no other health issues. The treatment of cases of sphincter mechanism incompetence may be difficult and most therapies correct only one of the above factors. Incurin. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. 20. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP). prnpharmacal.com/products/urinary-health/proin-chewable-tablets. There is considerable variation in urethral length between bitches of different sizes. So, we asked our vet about trying DES. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. Freedom of Information Summary. It's an estrogen supplement similar to DES, but shorter acting so it has to be given daily. The recommended dose of Proin ER is 2 to 4mg/kg PO q24h (to be given with food).10 Proin ER is available in 18-, 38-, 74-, and 145-mg tablets. NADA 141-325. Were sorry, but our website doesnt work properly without JavaScript enabled. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Nendick PA, Clark WT. An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. Proin does not work for dogs with urinary incontinence due to other medical conditions like malformations and neurologic disease. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. ), is preferable for patients with known behavioral concerns. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls. The information is NOT to be used for diagnosis or treatment of your pet. Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. 15% discount available for new customers only. This thread is archived . Phenylpropanolamine is a sympathomimetic amine that indirectly stimulates the 1 adrenergic receptors (and, to a lesser extent, -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter.7,8 It is also thought to prolong its effect by inhibiting norepinephrine reuptake at the synaptic junction.7 Phenylpropanolamine may have decreased efficacy in patients on long-term therapy owing to either depletion of norepinephrine stores or desensitization of the -adrenergic receptors.7-9, The recommended labeled dose for Proin is 2 mg/kg PO q12h, to be dosed to the nearest half-tablet.6 Proin is commercially available in 25-, 50-, and 75-mg tablets. Body size appears to be a factor since large and giant breeds are particularly at risk. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). Can be Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female beagle dogs. This is an automated general reminder to please follow The Sub Rules when discussing this question: Do not comment with anecdotes about your own or others' pets. OP, your post has NOT been removed. Common side effects of Proin in dogs include diarrhea, vomiting, loss of appetite, weight loss, irritability, restlessness, agitation, vocalization, difficulty urinating, increased thirst (polydipsia), increased water intake, and lethargy.